Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver | Zendy

Alessandro Malara | Zendy; Vittorio Abbonante | Zendy; Maria Zingariello | Zendy; Anna Ritá Migliaccio | Zendy; Alessandra Balduini | Zendy

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Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver

Author(s) -

Alessandro Malara,

Vittorio Abbonante,

Maria Zingariello,

Anna Ritá Migliaccio,

Alessandra Balduini

Publication year - 2018

Publication title -

mediterranean journal of hematology and infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 31

ISSN - 2035-3006

DOI - 10.4084/mjhid.2018.068

Subject(s) - myelofibrosis , bone marrow , megakaryocyte , medicine , stromal cell , fibrosis , pathology , dysplasia , hyperplasia , cancer research , haematopoiesis , biology , microbiology and biotechnology , stem cell

In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis.

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