Transfusion associated peak in Hb HPLC chromatogram – a case report | Zendy

Sonal Jain | Zendy; Jasmita Dass | Zendy; Hara Prasad Pati | Zendy

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Transfusion associated peak in Hb HPLC chromatogram – a case report

Author(s) -

Sonal Jain,

Jasmita Dass,

Hara Prasad Pati

Publication year - 2012

Publication title -

mediterranean journal of hematology and infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 31

ISSN - 2035-3006

DOI - 10.4084/mjhid.2012.006

Subject(s) - medicine , juvenile myelomonocytic leukemia , fetal hemoglobin , high performance liquid chromatography , chromatography , hemoglobin , pediatrics , fetus , pregnancy , chemistry , genetics , stem cell , haematopoiesis , biology

High performance liquid chromatography (HPLC) and electrophoresis are commonly used to diagnose various hemoglobinopathies. However, insufficient information about the transfusion history can lead to unexpected and confusing results. We are reporting a case of Juvenile myelomonocytic leukemia (JMML) in which HbHPLC was done to quantify fetal hemoglobin (HbF). The chromatogram showed elevated HbF along with a peak in the HbD window. A transfusion acquired peak was suspected based on the unexpectedly low percentage of HbD and was subsequently confirmed using parental HbHPLC.

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