ATRA induced Reactive Hemophagocytosis: A Case Report | Zendy

Monica Sharma | Zendy; Sanjeev K. Sharma | Zendy; Jasmita Dass | Zendy; Seema Tyagi | Zendy

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ATRA induced Reactive Hemophagocytosis: A Case Report

Author(s) -

Monica Sharma,

Sanjeev K. Sharma,

Jasmita Dass,

Seema Tyagi

Publication year - 2011

Publication title -

mediterranean journal of hematology and infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 31

ISSN - 2035-3006

DOI - 10.4084/mjhid.2011.034

Subject(s) - hemophagocytosis , histiocyte , medicine , acute promyelocytic leukemia , phagocytosis , retinoic acid , tretinoin , promyelocyte , leukemia , immunology , cancer research , histiocytosis , bone marrow , pathology , biology , disease , cell culture , pancytopenia , genetics

All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one may find phagocytosis of differentiated cells by histiocytes without the overt manifestations of hemophagocytic syndrome. We report a case of APL showing differentiated cells being phagocytosed by marrow histiocytes while patient was getting ATRA therapy.

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