5-Azacytidine in chronic myelomonocytic leukemia: case report and review of literature
Author(s) -
Mariangela Greco,
Marianna Criscuolo,
Luana Fianchi,
Emiliano Fabiani,
Livio Pagano,
Maria Teresa Voso
Publication year - 2011
Publication title -
mediterranean journal of hematology and infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 31
ISSN - 2035-3006
DOI - 10.4084/mjhid.2011.011
Subject(s) - azacitidine , medicine , chronic myelomonocytic leukemia , myelodysplastic syndromes , peripheral blood , oncology , hypomethylating agent , leukemia , toxicity , blood count , decitabine , bone marrow , dna methylation , genetics , biology , gene expression , gene
Hypomethylating drugs are useful in the management of Myelodysplastic syndromes, but there are only few reports on chronic myelomonocycitic (CMML) leukemia patients. We describe our experience in 3 CMML patients treated with azacitidine. Two patients obtained partial response after 4 treatment cycles with only minor toxicity and are in continuous partial response, with stable peripheral blood counts, at 29 and 30 cycles from treatment start.
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