Severe Acute Hepatitis B Treated with Entecavir | Zendy

Giuseppe Vittorio De Socio | Zendy; Alessio Sgrelli | Zendy; Andrea Tosti | Zendy; Franco Baldelli | Zendy

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Severe Acute Hepatitis B Treated with Entecavir

Author(s) -

Giuseppe Vittorio De Socio,

Alessio Sgrelli,

Andrea Tosti,

Franco Baldelli

Publication year - 2011

Publication title -

mediterranean journal of hematology and infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 31

ISSN - 2035-3006

DOI - 10.4084/mjhid.2011.010

Subject(s) - entecavir , hbsag , medicine , acute hepatitis , hepatitis a virus , hepatitis b virus , hepatitis b , virology , hepatitis , acute hepatitis b , gastroenterology , immunology , virus , lamivudine

Hepatitis B virus (HBV) infection constitutes a serious global health problem. Nowadays there are divergent data regarding the use of antiviral drugs to treat acute hepatitis B. We present here a case of a 62-year-old man affected by severe acute hepatitis B with progressive worsening of clinical and hepatic function. The patient was treated with entecavir without critical side effects. We observed rapid clinical and laboratory improvements and the disappearance of hepatitis B surface antigen (HBsAg). The treatment with entecavir was protracted until 17 th week when the antibody anti-HBs appeared. Entecavir should be carefully considered for the treatment of severe acute hepatitis B cases.

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