Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats | Zendy

P. Kaur | Zendy; Rajbir Kaur | Zendy; Rohit Arora | Zendy; Saroj Arora | Zendy

Open Access

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Author(s) -

P. Kaur,

Rajbir Kaur,

Rohit Arora,

Saroj Arora

Publication year - 2017

Publication title -

journal of xenobiotics

Language(s) - English

Resource type - Journals

eISSN - 2039-4713

pISSN - 2039-4705

DOI - 10.4081/xeno.2017.6475

Subject(s) - betulinic acid , dmba , chemistry , antioxidant , atpase , enzyme , in vivo , pharmacology , biochemistry , downregulation and upregulation , endocrinology , biology , carcinogenesis , genetics , microbiology and biotechnology , gene

3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo. The present study focuses its protective effect on polycyclic aromatic hydrocarbon (7,12- Dimethylbenz(a)anthracene or DMBA) induced alterations in membrane bound ATPases, detoxification enzymes and antioxidant enzymes in stomach and lungs of female Sprague Dawley rats. Healthy female Sprague Dawley rats were randomly assorted into six groups and the treatments were given orally for 7 weeks on alternate days. It was observed that betulinic acid facilitated the downregulation of elevated membrane bound ATPases (Na+/K+- ATPase, Ca2+-ATPase and Mg2+-ATPase) in DMBA administered rats. Likewise, the detoxification enzymes as well as antioxidant enzymes were modulated to normalcy in rats. Overall, betulinic acid was seen to be effective modulator of DMBA induced alterations in biochemical parameters

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