Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral RET Wild-Type Neoplasm with Revision of the Literature | Zendy

Gian Luca Rampioni Vinciguerra | Zendy; Niccolò Noccioli | Zendy; Claudia Cippitelli | Zendy; Angelo Minucci | Zendy; Ettore Capoluongo | Zendy; Armando Bartolazzi | Zendy

Open Access

Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral RET Wild-Type Neoplasm with Revision of the Literature

Author(s) -

Gian Luca Rampioni Vinciguerra,

Niccolò Noccioli,

Claudia Cippitelli,

Angelo Minucci,

Ettore Capoluongo,

Armando Bartolazzi

Publication year - 2016

Publication title -

rare tumors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 15

eISSN - 2036-3613

pISSN - 2036-3605

DOI - 10.4081/rt.2016.6537

Subject(s) - medicine , multiple endocrine neoplasia type 2 , medullary cavity , thyroid carcinoma , pathology , malignancy , multiple endocrine neoplasia , thyroid , ret proto oncogene , medullary carcinoma , endocrine system , mutation , germline mutation , gene , biology , biochemistry , hormone

Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. However in the Multiple Endocrine Neoplasia Syndrome 2, linked to the point mutation of RET oncogene, multifocal MTCs may also occur. Herein, we report the case of a 75 years old man with a rare form of sporadic multifocal and bilateral OV-MTC expressing wild-type RET gene. The histological and molecular features of this rare entity are pre sented and discussed with revision of the pertinent literature

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