T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma | Zendy

Pooja Advani | Zendy; Jason S. Starr | Zendy; Abhisek Swaika | Zendy; Liuyan Jiang | Zendy; Yushi Qiu | Zendy; Zhimin Li | Zendy; Han W. Tun | Zendy

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T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma

Author(s) -

Pooja Advani,

Jason S. Starr,

Abhisek Swaika,

Liuyan Jiang,

Yushi Qiu,

Zhimin Li,

Han W. Tun

Publication year - 2015

Publication title -

rare tumors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 15

eISSN - 2036-3613

pISSN - 2036-3605

DOI - 10.4081/rt.2015.6084

Subject(s) - histiocyte , lymphoma , pathology , medicine , diffuse large b cell lymphoma , b cell lymphoma , b cell , immunology , antibody

Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non-Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of abundant T-cells and histiocytes. This is in contrast to the dense perivascular cuffing of neoplastic B-cells in classic DLBCL. T-cell/histiocyte-rich large B-cell lymphoma should be considered in PCNSL cases in which neoplastic B-cells are sparse and scattered. Immunohistochemistry will help identify the B-cells and surrounding infiltrate rich in T-lymphocytes and histiocytes. Future studies exploring the biology of TCRLBCL and the crosstalk between the neoplastic cells and the surrounding inflammatory infiltrate may provide exciting prospects for future therapies for TCRLBCL

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