Response to radiation in renal medullary carcinoma | Zendy

Alexandra Walsh | Zendy; John B. Fiveash | Zendy; Alyssa Reddy | Zendy; Gregory K. Friedman | Zendy

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Response to radiation in renal medullary carcinoma

Author(s) -

Alexandra Walsh,

John B. Fiveash,

Alyssa Reddy,

Gregory K. Friedman

Publication year - 2011

Publication title -

rare tumors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 15

eISSN - 2036-3613

pISSN - 2036-3605

DOI - 10.4081/rt.2011.e32

Subject(s) - medicine , malignancy , medulla , medullary cavity , chemotherapy , radiation therapy , renal medulla , sickle cell trait , induction chemotherapy , oncology , radiology , disease , pathology

Renal Medullary Carcinoma (RMC) is a rare and highly aggressive malignancy arising from the renal medulla and found mostly in patients with sickle cell trait. RMC usually presents with widely metastatic disease. We describe a young man diagnosed with RMC who sustained a complete response to systemic chemotherapy but developed brain metastases with leptomeningeal involvement who had a partial response to brain irradiation. We discuss the use of radiation in RMC and propose upfront craniospinal irradiation as a reasonable addition to chemotherapy in order to give patients with metastatic RMC a chance at cure.

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