Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy | Zendy

Hiroki Goto | Zendy; Shotaro Hagiwara | Zendy; Risen Hirai | Zendy; T. Miyama | Zendy; Haruhito Honda | Zendy; Amane Tagashira | Zendy; Toshihiko Iizuka | Zendy; Makoto Mochizuki | Zendy; Katsuji Teruya | Zendy; Yoshimi Kikuchi | Zendy; Shinichi Oka | Zendy; Akiyoshi Miwa | Zendy

Open Access

Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy

Author(s) -

Hiroki Goto,

Shotaro Hagiwara,

Risen Hirai,

T. Miyama,

Haruhito Honda,

Amane Tagashira,

Toshihiko Iizuka,

Makoto Mochizuki,

Katsuji Teruya,

Yoshimi Kikuchi,

Shinichi Oka,

Akiyoshi Miwa

Publication year - 2011

Publication title -

rare tumors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 15

eISSN - 2036-3613

pISSN - 2036-3605

DOI - 10.4081/rt.2011.e11

Subject(s) - medicine , plasmablastic lymphoma , etoposide , salvage therapy , transplantation , lymphoma , autologous stem cell transplantation , stem cell , surgery , melphalan , malignancy , regimen , hematopoietic stem cell transplantation , oncology , chemotherapy , biology , genetics

Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation

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