Basal cell carcinoma with progression to metastatic neuroendocrine carcinoma | Zendy

Rajiv M. Patel | Zendy; Volkan Adsay | Zendy; Aleodor A. Andea | Zendy

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Basal cell carcinoma with progression to metastatic neuroendocrine carcinoma

Author(s) -

Rajiv M. Patel,

Volkan Adsay,

Aleodor A. Andea

Publication year - 2010

Publication title -

rare tumors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 15

eISSN - 2036-3613

pISSN - 2036-3605

DOI - 10.4081/rt.2010.e8

Subject(s) - chromogranin a , merkel cell carcinoma , neuroendocrine differentiation , merkel cell , medicine , pathology , cytokeratin , epidermis (zoology) , carcinoma , basal cell carcinoma , enolase , neuroendocrine carcinoma , immunohistochemistry , basal (medicine) , neuroendocrine tumors , cancer , anatomy , basal cell , prostate cancer , insulin

Merkel cell carcinoma (MCC) or primary cutaneous neuroendocrine carcinoma is a malignant tumor considered to demonstrate differentiation towards Merkel cells that are present at the base of the epidermis or around the apical end of some hair follicles and are thought to play an yet uncertain role in sensory transduction. Here we present the case of a 54-year-old female with a basal cell carcinoma (BCC) of the skin with neuroendocrine features (positivity for chromogranin) that has evolved during multiple recurrences and radiotherapy into a high-grade neuroendocrine carcinoma with morphologic and immunohistochemical features of MCC (trabecular and nesting arrangement, positivity for chromogranin, cytokeratin 20, neuron specific enolase, and also neurosecretory granules on electron microscopy). The progression from a chromogranin positive basal cell carcinoma of the skin, to a high grade neuroendocrine carcinoma demonstrates the potential for cross differentiation among skin tumors.

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