Familial adenomatous polyposis with synchronous invasive colonic carcinomas and metastatic jejunal adenocarcinoma in a Nigerian male | Zendy

Chukwuemeka Osuagwu | Zendy; Okechukwu Charles Okafor | Zendy; Emmanuel Ezeome | Zendy; Chrisogonus Ezenwa Uche | Zendy; Charles Ifeanyi Ememonu | Zendy; Emeka B Kesieme | Zendy

Open Access

Familial adenomatous polyposis with synchronous invasive colonic carcinomas and metastatic jejunal adenocarcinoma in a Nigerian male

Author(s) -

Chukwuemeka Osuagwu,

Okechukwu Charles Okafor,

Emmanuel Ezeome,

Chrisogonus Ezenwa Uche,

Charles Ifeanyi Ememonu,

Emeka B Kesieme

Publication year - 2010

Publication title -

rare tumors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.285

H-Index - 15

eISSN - 2036-3613

pISSN - 2036-3605

DOI - 10.4081/rt.2010.e66

Subject(s) - medicine , colorectal cancer , colonic carcinoma , adenocarcinoma , familial adenomatous polyposis , pathological , stage (stratigraphy) , jejunum , gastroenterology , chemotherapy , carcinoma , disease , cancer , oncology , paleontology , biology

Familial adenomatous polyposis is rare. Three cases were previously reported in Nigeria. An intriguing feature of this case is an ulcerated jejunal carcinoma which was metastatic rather than synchronous carcinoma. This patient presented with partial large bowel obstruction and the pathological analysis revealed 4 invasive adenocarcinomas, 3 in the colon and 1 in the jejunum (Dukes stage D). Palliative pancolectomy and jejunal tumour resection with chemotherapy was offered to him. He died eight months after surgery from disease progression. The challenges of managing a hereditary cancer syndrome in a resource poor country are highlighted

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