The basic science of bone marrow aspirate concentrate in chondral injuries | Zendy

James M. Holton | Zendy; Mohamed A. Imam | Zendy; J. Ward | Zendy; Martyn Snow | Zendy

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The basic science of bone marrow aspirate concentrate in chondral injuries

Author(s) -

James M. Holton,

Mohamed A. Imam,

J. Ward,

Martyn Snow

Publication year - 2016

Publication title -

orthopedic reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.412

H-Index - 13

eISSN - 2035-8237

pISSN - 2035-8164

DOI - 10.4081/or.2016.6659

Subject(s) - medicine , bone marrow aspirate , regeneration (biology) , mesenchymal stem cell , cartilage , bone marrow , stem cell , surgery , pathology , microbiology and biotechnology , anatomy , biology

There has been great interest in bone marrow aspirate concentrate (BMAC) as a cost effective method in delivering mesenchymal stem cells (MSCs) to aid in the repair and regeneration of cartilage defects. Alongside MSCs, BMAC contains a range of growth factors and cytokines to support cell growth following injury. However, there is paucity of information relating to the basic science underlying BMAC and its exact biological role in supporting the growth and regeneration of chondrocytes. The focus of this review is the basic science underlying BMAC in relation to chondral damage and regeneration

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