Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease | Zendy

Pierachille Santus | Zendy; F. Casanova | Zendy; M.L. Biondi | Zendy; Francesco Blasi | Zendy; Fabiano Di Marco | Zendy; Stefano Centanni | Zendy

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Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease

Author(s) -

Pierachille Santus,

F. Casanova,

M.L. Biondi,

Francesco Blasi,

Fabiano Di Marco,

Stefano Centanni

Publication year - 2016

Publication title -

monaldi archives for chest disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.196

H-Index - 46

eISSN - 2465-101X

pISSN - 1122-0643

DOI - 10.4081/monaldi.2009.371

Subject(s) - pulmonary disease , medicine , disease , polymorphism (computer science) , risk factor , genetics , biology , genotype , gene

Chronic obstructive lung disease (COPD) is characterised by partially reversible usually progressive airflow limitation caused by inflammation and remodelling. Stromelysin-1 (MMP-3) has regulatory activity on other matrix-metalloproteinases. Altered MMP-3 activity has been described in different diseases. We investigated the role of a promoter MMP-3 polymorphism in determining susceptibility and severity of COPD.

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