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Hypersexuality and gender dysphoria have both been described in the literature as symptoms of mania. Hypersexuality is listed in the <em>Diagnostic and Statistical Manual of Mental Disorders 5</em> as part of the diagnostic criteria for bipolar disorder. Gender dysphoria is less often described and its relation to mania remains unclear. This case report describes a young homosexual man presenting in a manic episode with co-morbid amphetamine abuse whose mania was marked by hypersexuality and the new onset desire to be a woman. Both of these symptoms resolved with the addition of valproic acid to antipsychotics. This case report presents the existing literature on hypersexuality and gender dysphoria in mania and describes a treatment option that has not been previously reported

A case of mania presenting with hypersexual behavior and gender dysphoria that resolved with valproic acid