APOBEC3G expression and HIV-1 infection in Burkina Faso | Zendy

Tégwindé Rebeca Compaore | Zendy; Serge Théophile Soubeïga | Zendy; Abdoul Karim Ouattara | Zendy; Daméhan Tchelougou | Zendy; Cyrille Bisseyé | Zendy; Didier Romuald Bakouan | Zendy; Issaka Pierre Compaore | Zendy; Augustine Dembele | Zendy; Albert Théophane Yonli | Zendy; Dorcas ObiriYeboah | Zendy; Florencia Wendkuuni Djigma | Zendy; Jacques Simporé | Zendy

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APOBEC3G expression and HIV-1 infection in Burkina Faso

Author(s) -

Tégwindé Rebeca Compaore,

Serge Théophile Soubeïga,

Abdoul Karim Ouattara,

Daméhan Tchelougou,

Cyrille Bisseyé,

Didier Romuald Bakouan,

Issaka Pierre Compaore,

Augustine Dembele,

Albert Théophane Yonli,

Dorcas ObiriYeboah,

Florencia Wendkuuni Djigma,

Jacques Simporé

Publication year - 2018

Publication title -

journal of public health in africa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.292

H-Index - 12

eISSN - 2038-9930

pISSN - 2038-9922

DOI - 10.4081/jphia.2018.907

Subject(s) - apobec3g , virology , biology , cytidine deaminase , samhd1 , human immunodeficiency virus (hiv) , allele , complementary dna , genetics , viral replication , microbiology and biotechnology , virus , reverse transcriptase , gene , polymerase chain reaction

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, expression in subjects' naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of mRNA than the controls carriers of the G minor allele. polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

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