A Unique Case of Durable Complete Remission after Salvage with Azacitidine and DLI for High Risk FLT-3 Positive Acute Myeloid Leukemia, Following Relapse 18 Months Post Allogeneic Stem Cell Transplant
Author(s) -
Claire Horgan,
Alexandros Kanellopoulos,
Shankara Paneesha,
Bhuvan Kishore,
Richard Lovell,
Emmanouil Nikolousis
Publication year - 2019
Publication title -
hematology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.239
H-Index - 12
ISSN - 2038-8330
DOI - 10.4081/hr.2019.7800
Subject(s) - medicine , azacitidine , myeloid leukemia , complete remission , salvage therapy , refractory (planetary science) , oncology , stem cell , donor lymphocyte infusion , transplantation , hematopoietic stem cell transplantation , chemotherapy , biochemistry , gene expression , chemistry , physics , genetics , astrobiology , biology , dna methylation , gene
A unique case of primary refractory FLT3-itd mutated acute myeloid leukemia in an elderly patient, who achieved completed morphological remission, and FLT3-itd negativity, following 9 cycles of azacitadine in combination with escalating doses of donor lymphocyte infusions following relapse 18 months post reduced intensity HLAA mismatch Campath conditioning allogeneic stem cell transplant.
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