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Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
Author(s) -
Miriam Conces,
Rolla AbuArja,
Suzanne Reed,
Hemalatha G. Rangarajan,
Terri Guinipero,
Michael R. Loken,
Lisa Eidenschink Brodersen,
Samir B. Kahwash
Publication year - 2017
Publication title -
hematology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.239
H-Index - 12
ISSN - 2038-8330
DOI - 10.4081/hr.2017.7057
Subject(s) - immunophenotyping , medicine , myeloid leukemia , leukemia , myeloid , pathology , immunology , flow cytometry
The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype

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