A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve | Zendy

Marco Patruno | Zendy; Luca Melotti | Zendy; Chiara Gomiero | Zendy; Roberta Sacchetto | Zendy; Ohad Topel | Zendy; Tiziana Martinello | Zendy

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A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve

Author(s) -

Marco Patruno,

Luca Melotti,

Chiara Gomiero,

Roberta Sacchetto,

Ohad Topel,

Tiziana Martinello

Publication year - 2017

Publication title -

european journal of translational myology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.271

H-Index - 6

eISSN - 2037-7460

pISSN - 2037-7452

DOI - 10.4081/ejtm.2017.6039

Subject(s) - myod , transcription (linguistics) , microbiology and biotechnology , computational biology , fusion protein , peptide , cell , chemistry , transcription factor , biology , recombinant dna , gene , biochemistry , philosophy , linguistics

The transcriptional activator TAT is a small peptide essential for viral replication and possesses the property of entering the cells from the extracellular milieu, acting as a membrane shuttle. In order to safely differentiate cells an innovative methodology, based on the fusion of transcription factors and the TAT sequence, is discussed in this short review. In several studies, it has been demonstrated that TAT protein can be observed in the cell nucleus after few hours from the inoculation although its way of action is not fully understood. However, further studies will be necessary to develop this methodology for clinical purposes

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