Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes | Zendy

Hongli Hu | Zendy; Xing Meng | Zendy

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Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes

Author(s) -

Hongli Hu,

Xing Meng

Publication year - 2016

Publication title -

european journal of translational myology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.271

H-Index - 6

eISSN - 2037-7460

pISSN - 2037-7452

DOI - 10.4081/ejtm.2016.5805

Subject(s) - ryanodine receptor , endoplasmic reticulum , triad (sociology) , ryanodine receptor 2 , ryr1 , receptor , vesicle , skeletal muscle , biophysics , transmembrane protein , transmembrane domain , chemistry , anatomy , biology , membrane , microbiology and biotechnology , biochemistry , psychology , psychoanalysis

Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the connection angles were rotated along the transmembrane axis of ryanodine receptors. Majority of the connections was observed at domains 6/6 of ryanodine receptors while a small group of connections were showed at domains 9/10. The flexible rotation and connection shift seem to facilitate the extension of an annular network on the wall of the sarcoplasmic reticulum in a triad

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