Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats | Zendy

Jun Liu | Zendy; Linbin Cai | Zendy; Yuanyuan He | Zendy; Jun Yang | Zendy

Open Access

Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats

Author(s) -

Jun Liu,

Linbin Cai,

Yuanyuan He,

Jun Yang

Publication year - 2017

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2017.2706

Subject(s) - cochlea , apoptosis , biology , caspase 3 , in vivo , microbiology and biotechnology , organ culture , programmed cell death , andrology , medicine , endocrinology , pathology , anatomy , genetics , in vitro

Kölliker’s organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5’-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To reveal the apoptosis of Kölliker’s organ in new-born rats, we studied the morphological changes and expression of apoptosis-related factors during early postnatal development. We found SCs in Kölliker’s organ decreased in number and changed in appearance along the cochlea apex-to-base gradient, and the expression of caspase-3, caspase-8, caspase-9 and bcl-2 in Kölliker’s organ of the cochlea fluctuated along the course of postnatal development, with an expression peak at postnatal day 3. This study demonstrates a time-dependent degeneration of Kölliker’s organ during postnatal cochlea development, which might be triggered by endogenous factors.

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