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In vivo imaging techniques: a new era for histochemical analysis
Author(s) -
Alice Busato,
Paolo Fumene Feruglio,
Pier Paolo Parnigotto,
Pasquina Marzola,
Andrea Sbarbati
Publication year - 2016
Publication title -
european journal of histochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 42
eISSN - 2038-8306
pISSN - 1121-760X
DOI - 10.4081/ejh.2016.2725
Subject(s) - magnetic resonance imaging , diffusion mri , in vivo , preclinical imaging , biomedical engineering , molecular imaging , magnetic resonance spectroscopic imaging , high resolution , nuclear magnetic resonance , microscopy , magnetic resonance microscopy , materials science , computer science , pathology , medicine , radiology , biology , physics , spin echo , geology , remote sensing , microbiology and biotechnology

In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.

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