Species diversity regarding the presence of proximal tubular progenitor cells of the kidney | Zendy

J. Hansson | Zendy; Anette Ericsson | Zendy; Håkan Axelson | Zendy; Mats E. Johansson | Zendy

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Species diversity regarding the presence of proximal tubular progenitor cells of the kidney

Author(s) -

J. Hansson,

Anette Ericsson,

Håkan Axelson,

Mats E. Johansson

Publication year - 2016

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2016.2567

Subject(s) - progenitor cell , regeneration (biology) , progenitor , kidney , population , renal stem cell , biology , pathology , phenotype , microbiology and biotechnology , anatomy , stem cell , medicine , endocrinology , gene , biochemistry , environmental health

The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.

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