Development of synovial membrane in the temporomandibular joint of the human fetus
Author(s) -
Luís Otávio Carvalho de Moraes,
Roberto Tedesco,
Luis Alfonso ArráezAybar,
Ophir D. Klein,
J.R. Mérida-Velasco,
Luís Garcia Alonso
Publication year - 2015
Publication title -
european journal of histochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 42
eISSN - 2038-8306
pISSN - 1121-760X
DOI - 10.4081/ejh.2015.2569
Subject(s) - synovial membrane , cd68 , fetus , temporomandibular joint , pathology , immunohistochemistry , medicine , anatomy , macrophage , synovial joint , chemistry , biology , arthritis , pregnancy , osteoarthritis , biochemistry , in vitro , genetics , alternative medicine , articular cartilage
The development of the synovial membrane was analyzed in serial sections of 21 temporomandibular joints of human fetuses at 9 to 13 weeks of gestation. Sections of two fetuses at 12 weeks of development were used to perform immunohistochemical expression of the markers CD68 and Hsp27 on the synovial lining. Macrophage-like type A and fibroblast-like type B cells, which express CD68 and Hsp27, respectively, were observed at the twelfth week of development. Our results suggest that the development of the synovial membrane is related to the vascularization of the joint and the formation of the articular cavities
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