Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription | Zendy

Manuela Costanzo | Zendy; Barbara Cisterna | Zendy; Antonio Vella | Zendy; Tiziana Cestari | Zendy; Viviana Covi | Zendy; Gabriele Tabaracci | Zendy; Manuela Malatesta | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription

Author(s) -

Manuela Costanzo,

Barbara Cisterna,

Antonio Vella,

Tiziana Cestari,

Viviana Covi,

Gabriele Tabaracci,

Manuela Malatesta

Publication year - 2015

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2015.2515

Subject(s) - cytoskeleton , microbiology and biotechnology , ozone , cell , mitochondrion , biology , chemistry , biophysics , biochemistry , organic chemistry

Ozone therapy is a modestly invasive procedure based on the regeneration capabilities of low ozone concentrations and used in medicine as an alternative/adjuvant treatment for different diseases. However, the cellular mechanisms accounting for the positive effects of mild ozonization are still largely unexplored. To this aim, in the present study the effects of low ozone concentrations (1 to 20 µg O₃/mL O₂) on structural and functional cell features have been investigated in vitro by using morphological, morphometrical, cytochemical and immunocytochemical techniques at bright field, fluorescence and transmission electron microscopy. Cells exposed to pure O₂ or air served as controls. The results demonstrated that the effects of ozoneadministration are dependent on gas concentration, and the cytoskeletal organization, mitochondrial activity and nuclear transcription may be differently affected. This suggests that, to ensure effective and permanent metabolic cell activation, ozone treatments should take into account the cytological and cytokinetic features of the different tissues.