Immunolocalization of NGF and its receptors in ovarian surface epithelium of the wild ground squirrel during the breeding and nonbreeding seasons | Zendy

Lihong Bao | Zendy; Qinglin Li | Zendy; Yue Liu | Zendy; B. Li | Zendy; Xia Sheng | Zendy; Yingying Han | Zendy; Qihao Weng | Zendy

Open Access

Immunolocalization of NGF and its receptors in ovarian surface epithelium of the wild ground squirrel during the breeding and nonbreeding seasons

Author(s) -

Lihong Bao,

Qinglin Li,

Yue Liu,

B. Li,

Xia Sheng,

Yingying Han,

Qihao Weng

Publication year - 2014

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2014.2363

Subject(s) - biology , immunostaining , tropomyosin receptor kinase a , endocrinology , medicine , seasonal breeder , receptor tyrosine kinase , low affinity nerve growth factor receptor , nerve growth factor , receptor , ground squirrel , epithelium , immunohistochemistry , zoology , thermoregulation , immunology , genetics

The ovarian surface epithelium (OSE) plays an important role in normal ovarian physiology. During each reproductive cycle, the OSE takes part in the cyclical ovulatory ruptures and repair. The aim of this study was to investigate the immunolocalization of nerve growth factor (NGF) and its receptors, tyrosine kinase A (TrkA) and p75, in the OSE cells of the wild ground squirrels during the breeding and nonbreeding seasons. There were marked variations in ovarian weight and size between the breeding and the nonbreeding seasons. Histologically, cuboidal cells and squamous cells were identified in the OSE of both seasons. Yet, stronger immunostaining of NGF, TrkA and p75 were observed in cuboidal cells and squamous cells in the breeding season as compared to the nonbreeding season. In addition, plasma gonadotropin concentrations were higher in the breeding season than in the nonbreeding season, suggesting that the expression patterns of NGF, TrkA and p75 in the OSE were correlated with changes in plasma gonadotropins. These findings suggested that NGF and its receptor TrkA and p75 may be involved in the regulation of seasonal changes in the OSE of wild ground squirrel.in the OSE of wild ground squirrel

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