dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas | Zendy

Yidong Zhang | Zendy; W.Y. Ye | Zendy; J.Q. Wang | Zendy; Shuchen Wang | Zendy; Ping Ji | Zendy; Ge Zhou | Zendy; Guoping Zhao | Zendy; Haibo Ge | Zendy; Y. Wang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas

Author(s) -

Yidong Zhang,

W.Y. Ye,

J.Q. Wang,

Shuchen Wang,

Ping Ji,

Ge Zhou,

Guoping Zhao,

Haibo Ge,

Y. Wang

Publication year - 2013

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2013.e29

Subject(s) - nucleus , biology , dna , cancer , nucleic acid , cancer cell , cell nucleus , nucleotide , cell , cytosol , cancer research , microbiology and biotechnology , biochemistry , genetics , enzyme , gene

Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) functions as one of the mechanisms to guarantee the fidelity of DNA replication through the cleavage of non-canonical nucleotides into di- or monophosphates. Human NTP-PPase is poorly understood and investigated. In the present study, by using tissue microassays with the paired cancer and adjacent regions, we found that with the prevalent expression of dCTP pyrophosphohydrase (DCTPP1) in the cytosol and nucleus in tumors investigated, DCTPP1 was inclined to accumulate in the nucleus of cancer cells compared to the paired adjacent tissue cells in multiple carcinoma including lung, breast, liver, cervical, gastric and esophagus cancer. More significantly, the higher DCTPP1 expression in the nucleus of lung, gastric and esophagus cancer cells was associated with histological subtypes. The nucleic accumulation of DCTPP1 was apparently observed as well when cancer cell line MCF-7 was treated with H₂O₂ in vitro. Considering the roles of DCTPP1 on restricting the concentration of non-canonical nucleotides in the nucleotide pool, accumulation of DCTPP1 in the nucleus of cancer cells might suffice for maintaining the proper DNA replication in order to fulfill the requirement for the survival and proliferation of tumor cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research