Expression of SP-C and Ki67 in lungs of preterm infants dying from respiratory distress syndrome | Zendy

Hongyan Lu | Zendy; Wei Li | Zendy; Genbao Shao | Zendy; H. Wang | Zendy

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Expression of SP-C and Ki67 in lungs of preterm infants dying from respiratory distress syndrome

Author(s) -

Hongyan Lu,

Wei Li,

Genbao Shao,

H. Wang

Publication year - 2012

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2012.e35

Subject(s) - respiratory distress , medicine , autopsy , ventilation (architecture) , pathological , pulmonary surfactant , respiratory system , mechanical ventilation , neonatal respiratory distress syndrome , lung , gastroenterology , pediatrics , anesthesia , gestational age , biology , pregnancy , mechanical engineering , biochemistry , engineering , genetics

This study aimed at exploring the expression of Surfactant protein-C (SP-C) and Ki67 in autopsy lung tissues of premature infants dying from respiratory distress syndrome (RDS) who were exposed to mechanical ventilation and elevated oxygen concentrations. The possible influence of pulmonary surfactant (PS) on the expression of SP-C and Ki67 was also investigated. Thirty preterm infants were selected who were histologically and clinically diagnosed as RDS. Preterm infants with RDS were divided into 4 groups, according to the time of death: infants ventilated for 1-3 days, 4-8 days, 9-16 days and >6 days. Five premature infants died within 1 day after delivery for non- pulmonary reasons served as controls. The expression of SP-C and Ki67 in lungs was detected by immunohistochemistry. Compared with the control group, the expression of SP-C and Ki67 in RDS infants decreased significantly after 1-3 days of ventilation, but increased after 4 days and reached peak value after 9-16 days. No significant difference in the expression of SP-C and Ki67 was found between infants treated with PS and those without. Thus our results suggest SP-C and Ki67 may have participated in the pulmonary pathological process in ventilated/oxygen treated preterm infants with RDS, and exogenous surfactant had no effect on the expression of SP-C and Ki67 in the lungs of ventilated/oxygen treated preterm infants with RDS

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