Discrete foci containing RNAse A are found in nucleoli of HeLa cells after aging in culture | Zendy

Manuela Costanzo | Zendy; Barbara Cisterna | Zendy; O. O. Zharskaya | Zendy; О. В. Зацепина | Zendy; Marco Biggiogera | Zendy

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Discrete foci containing RNAse A are found in nucleoli of HeLa cells after aging in culture

Author(s) -

Manuela Costanzo,

Barbara Cisterna,

O. O. Zharskaya,

О. В. Зацепина,

Marco Biggiogera

Publication year - 2011

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2011.e15

Subject(s) - nucleolus , rnase p , hela , rna , immunocytochemistry , ribosomal rna , microbiology and biotechnology , cell culture , biology , cell , ultrastructure , chemistry , cytoplasm , biochemistry , genetics , anatomy , gene , endocrinology

We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNAse A, can be detected within nucleoli of aged cells. These bodies also contain RNA and lack ribosomal S3 proteins, and may represent either simple storage sites or areas where RNA degradation takes place

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