Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ | Zendy

Manuela Malatesta | Zendy; G. Meola | Zendy

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Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ

Author(s) -

Manuela Malatesta,

G. Meola

Publication year - 2010

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2010.e44

Subject(s) - myotonic dystrophy , wasting , skeletal muscle , sarcopenia , biology , cell nucleus , microbiology and biotechnology , pathogenesis , phenotype , dystrophy , pathological , nucleus , rna splicing , pathology , rna , medicine , endocrinology , genetics , gene

The histochemical and ultrastructural analysis of the nuclear components involved in RNA transcription and splicing can reveal the occurrence of cellular dysfunctions eventually related to the onset of a pathological phenotype. In recent years, nuclear histochemistry at light and electron microscopy has increasingly been used to investigate the basic mechanisms of skeletal muscle diseases; the study in situ of nuclei of myofibres and satellite cells proved to be crucial for understanding the pathogenesis of skeletal muscle wasting in sarcopenia, myotonic dystrophy and laminopathies.

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