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AML both in genotypes (OR=2.335; 95% CI: 1.056 ∼5.165, p=0.032) and in allele frequency (OR=2.417; 95% CI: 1.118∼5.228, p=0.021). Other SNPs except V384D were not associated with AML. The allele frequency of the SNPs between Asians, European descendants, and Africans was very significantly different (p<0.01), respectively. Among Asians, that of Koreans and Japanese was similar (p>0.05), while that between Korean and Chinese, and that between Japanese and Chinese were significantly different (p< 0.05). The data suggests that V384D polymorphism of hMLH1 might be associated with AML.

Association Study of hMLH1 Polymorphisms with Risk of Acute Myeloid Leukemia in Korean