Association Study of hMLH1 Polymorphisms with Risk of Acute Myeloid Leukemia in Korean | Zendy

Zhe Cheng | Zendy; Xue Mei Jin | Zendy; HyeoungJoon Kim | Zendy; Sang Woo Juhng | Zendy; Chan Choi | Zendy

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Association Study of hMLH1 Polymorphisms with Risk of Acute Myeloid Leukemia in Korean

Author(s) -

Zhe Cheng,

Xue Mei Jin,

HyeoungJoon Kim,

Sang Woo Juhng,

Chan Choi

Publication year - 2008

Publication title -

chonnam medical journal

Language(s) - English

Resource type - Journals

ISSN - 0377-9564

DOI - 10.4068/cmj.2008.44.1.23

Subject(s) - medicine , myeloid leukemia , genetic association , association (psychology) , oncology , single nucleotide polymorphism , genotype , genetics , gene , philosophy , epistemology , biology

AML both in genotypes (OR=2.335; 95% CI: 1.056 ∼5.165, p=0.032) and in allele frequency (OR=2.417; 95% CI: 1.118∼5.228, p=0.021). Other SNPs except V384D were not associated with AML. The allele frequency of the SNPs between Asians, European descendants, and Africans was very significantly different (p<0.01), respectively. Among Asians, that of Koreans and Japanese was similar (p>0.05), while that between Korean and Chinese, and that between Japanese and Chinese were significantly different (p< 0.05). The data suggests that V384D polymorphism of hMLH1 might be associated with AML.

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