Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 | Zendy

Lucidio Cristovão Fardelone | Zendy; J. Augusto R. Rodrigues | Zendy; Paulo J. S. Moran | Zendy

Open Access

Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182

Author(s) -

Lucidio Cristovão Fardelone,

J. Augusto R. Rodrigues,

Paulo J. S. Moran

Publication year - 2011

Publication title -

enzyme research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.439

H-Index - 39

eISSN - 2090-0406

pISSN - 2090-0414

DOI - 10.4061/2011/976368

Subject(s) - geotrichum , rhodotorula , enantioselective synthesis , yield (engineering) , chemistry , enantiomer , stereochemistry , enantiomeric excess , medicinal chemistry , organic chemistry , catalysis , biochemistry , yeast , food science , materials science , metallurgy

Enantioselective reductions of p-R1-C6H4C(O)CH2R2 (R1 = Cl, Br, CH3, OCH3, NO2 and R2 = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries

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