Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? | Zendy

Eduardo Mansilla | Zendy; Vanina Díaz Aquino | Zendy; Daniel Zambón | Zendy; Gustavo H. Marín | Zendy; Karina Mártire | Zendy; Gustavo Roque | Zendy; Thomas E. Ichim | Zendy; Neil H Riordan | Zendy; Amit N. Patel | Zendy; F. Sturla | Zendy; Gustavo Larsen | Zendy; Rubén Spretz | Zendy; Luis Núñez | Zendy; Carlos Soratti | Zendy; Ricardo Ibar | Zendy; M. van Leeuwen | Zendy; José María Tau | Zendy; Hugo Drago | Zendy; Alberto Maceira | Zendy

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Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?

Author(s) -

Eduardo Mansilla,

Vanina Díaz Aquino,

Daniel Zambón,

Gustavo H. Marín,

Karina Mártire,

Gustavo Roque,

Thomas E. Ichim,

Neil H Riordan,

Amit N. Patel,

F. Sturla,

Gustavo Larsen,

Rubén Spretz,

Luis Núñez,

Carlos Soratti,

Ricardo Ibar,

M. van Leeuwen,

José María Tau,

Hugo Drago,

Alberto Maceira

Publication year - 2011

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.4061/2011/943216

Subject(s) - progeria , mesenchymal stem cell , stem cell , metabolic syndrome , bioinformatics , medicine , lipodystrophy , mechanism (biology) , biology , endocrinology , pathology , obesity , immunology , genetics , philosophy , epistemology , human immunodeficiency virus (hiv) , gene , antiretroviral therapy , viral load

One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.

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