Biomarkers for Microglial Activation in Alzheimer's Disease | Zendy

Ronald Lautner | Zendy; Niklas Mattsson | Zendy; Michael Schöll | Zendy; Kristin Augutis | Zendy; Kaj Blennow | Zendy; Bob Olsson | Zendy; Henrik Zetterberg | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Biomarkers for Microglial Activation in Alzheimer's Disease

Author(s) -

Ronald Lautner,

Niklas Mattsson,

Michael Schöll,

Kristin Augutis,

Kaj Blennow,

Bob Olsson,

Henrik Zetterberg

Publication year - 2011

Publication title -

international journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.657

H-Index - 49

eISSN - 2090-8024

pISSN - 2090-0252

DOI - 10.4061/2011/939426

Subject(s) - neuroinflammation , microglia , neuroprotection , neuroscience , neurotoxicity , central nervous system , innate immune system , disease , neurodegeneration , medicine , immune system , alzheimer's disease , pathogenesis , neuroimaging , inflammation , immunology , biology , pathology , toxicity

Intensive research over the last decades has provided increasing evidence for neuroinflammation as an integral part in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Inflammatory responses in the central nervous system (CNS) are initiated by activated microglia, representing the first line of the innate immune defence of the brain. Therefore, biochemical markers of microglial activation may help us understand the underlying mechanisms of neuroinflammation in AD as well as the double-sided qualities of microglia, namely, neuroprotection and neurotoxicity. In this paper we summarize candidate biomarkers of microglial activation in AD along with a survey of recent neuroimaging techniques.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research