Prevalence of Mycobacterium tuberculosis in Taiwan: A Model for Strain Evolution Linked to Population Migration | Zendy

Horng-Yunn Dou | Zendy; ShuChen Huang | Zendy; IhJen Su | Zendy

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Prevalence of Mycobacterium tuberculosis in Taiwan: A Model for Strain Evolution Linked to Population Migration

Author(s) -

Horng-Yunn Dou,

ShuChen Huang,

IhJen Su

Publication year - 2011

Publication title -

international journal of evolutionary biology

Language(s) - English

Resource type - Journals

eISSN - 2090-8032

pISSN - 2090-052X

DOI - 10.4061/2011/937434

Subject(s) - mycobacterium tuberculosis , context (archaeology) , tuberculosis , strain (injury) , population , colonization , transmission (telecommunications) , ethnic group , biology , evolutionary biology , demography , microbiology and biotechnology , medicine , pathology , anthropology , sociology , paleontology , electrical engineering , anatomy , engineering

The global evolution and spread of Mycobacterium tuberculosis (MTB), one of the most successful bacterial pathogens, remain a mystery. Advances in molecular technology in the past decade now make it possible to understand MTB strain evolution and transmission in the context of human population migration. Taiwan is a relatively isolated island, serving as a mixing vessel over the past four centuries as colonization by different waves of ethnic groups occurred. By using mycobacterial tandem repeat sequences as genetic markers, the prevalence of MTB strains in Taiwan revealed an interesting association with historical migrations of different ethnic populations, thus providing a good model to explore the global evolution and spread of MTB

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