Evaluation of Transforming Growth Factor Beta-1 Gene 869T/C Polymorphism with Hypertension: A Meta-Analysis | Zendy

Wenquan Niu | Zendy

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Evaluation of Transforming Growth Factor Beta-1 Gene 869T/C Polymorphism with Hypertension: A Meta-Analysis

Author(s) -

Wenquan Niu

Publication year - 2011

Publication title -

international journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.744

H-Index - 37

eISSN - 2090-0392

pISSN - 2090-0384

DOI - 10.4061/2011/934265

Subject(s) - confidence interval , odds ratio , medicine , meta analysis , allele , genetic model , polymorphism (computer science) , bioinformatics , gene , genetics , biology

Association between transforming growth factor beta-1 gene (TGFB1) 869T/C polymorphism and hypertension has been widely evaluated, yet with conflicting results. As meta-analysis is a reliable way to resolve discrepancies; I aimed to evaluate this association. Data were available from 9 study populations involving 6151 subjects. Overall, comparison of allele 869C with 869T generated a significant 30% increased hypertension risk (95% confidence interval [95% CI]: 1.11–1.51; P=0.001), which was strengthened for homozygous comparison (869CC versus 869TT) with odds ratio (OR) doubled to 1.62 (95% CI: 1.23–2.14; P=0.001). Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies with OR, except in the dominant model, being increased by 7.94–18.61%. Likewise, ethnicity-based analysis exhibited a contradictory association between Asians and Whites. Conclusively, these findings support the notion that TGFB1 gene 869T/C polymorphism may influence the risk of hypertension, especially in Asian populations

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