LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation | Zendy

Magda Targa Martins | Zendy; Clésio Soldateli Paim | Zendy; Martin Steppe | Zendy

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LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation

Author(s) -

Magda Targa Martins,

Clésio Soldateli Paim,

Martin Steppe

Publication year - 2011

Publication title -

chromatography research international

Language(s) - English

Resource type - Journals

eISSN - 2090-3510

pISSN - 2090-3502

DOI - 10.4061/2011/860168

Subject(s) - lamotrigine , triethylamine , chromatography , methanol , ultraviolet , chemistry , analytical chemistry (journal) , materials science , medicine , optoelectronics , organic chemistry , epilepsy , psychiatry

Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achieved with a photodiode array at 279 nm. The detection response for LTG was linear (2=0.9999). The specificity and stability were proved using stress conditions. The CV (%) values for intraday and interday precision were less than 2.0%. The method was accurate and robust. The -student test proved that the LC and UV methods are interchangeable

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