Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds | Zendy

Kazuhito Tanabe | Zendy; Takeo Itô | Zendy; Seiichi Nishimoto | Zendy

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Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds

Author(s) -

Kazuhito Tanabe,

Takeo Itô,

Seiichi Nishimoto

Publication year - 2011

Publication title -

journal of nucleic acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.621

H-Index - 32

eISSN - 2090-021X

pISSN - 2090-0201

DOI - 10.4061/2011/816207

Subject(s) - disulfide bond , combinatorial chemistry , radiolysis , deoxyribozyme , computational biology , molecule , chemistry , nanotechnology , biophysics , dna , materials science , biochemistry , biology , organic chemistry , radical

A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.

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