Open AccessCircadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat
Author(s) -
Chikodi N. Anigbogu,
Daniel T. Williams,
David R. Brown,
Dennis L. Silcox,
Richard O. Speakman,
Laura Brown,
Dennis G. Karounos,
David C. Randall
Publication year - 2011
Publication title -
international journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 37
eISSN - 2090-0392
pISSN - 2090-0384
DOI - 10.4061/2011/738689
Subject(s) - diabetes mellitus , medicine , circadian rhythm , correlation coefficient , coefficient of variation , endocrinology , blood pressure , correlation , heart rate , cardiology , machine learning , mathematics , statistics , geometry , computer science
Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n=8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03; P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease
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