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The moss  Physcomitrella patens  has a great potential as a model system to perform functional studies of plant interacting with microbial pathogens.  P. patens  is susceptible to fungal and oomycete infection, which colonize and multiply in plant tissues generating disease symptoms. In response to infection,  P. patens  activates defense mechanisms similar to those induced in flowering plants, including the accumulation of reactive oxygen species, cell death with hallmarks of programmed cell death, cell wall fortification, and induction of defense-related genes like  PAL ,  LOX ,  CHS , and  PR-1 . Functional analysis of genes with possible roles in defense can be performed due to the high rate of homologous recombination present in this plant that enables targeted gene disruption. This paper reviews the current knowledge of defense responses activated in  P. patens  after pathogen assault and analyzes the advantages of using this plant to gain further insight into plant defense strategies.

The MossPhyscomitrella patensas a Model System to Study Interactions between Plants and Phytopathogenic Fungi and Oomycetes