Open AccessChromatin Modifying Agents in theIn VitroProduction of Bovine Embryos
Author(s) -
Fábio Morato Monteiro,
Clara Slade Oliveira,
Letícia Zoccolaro Oliveira,
Naiara Zoccal Saraiva,
Maria Eugênia Zerlotti Mercadante,
Flávia L. Lopes,
Daniel R. Arnold,
Joaquim Mansano Garcia
Publication year - 2010
Publication title -
veterinary medicine international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 30
eISSN - 2090-8113
pISSN - 2042-0048
DOI - 10.4061/2011/694817
Subject(s) - reprogramming , chromatin , epigenetics , cloning (programming) , embryo , biology , in vitro , chromatin remodeling , microbiology and biotechnology , somatic cell nuclear transfer , computational biology , genetics , gene , blastocyst , computer science , embryogenesis , programming language
The low efficiency observed in cloning by nuclear transfer is related to an aberrant gene expression following errors in epigenetic reprogramming. Recent studies have focused on further understanding of the modifications that take place in the chromatin of embryos during the preimplantation period, through the use of chromatin modifying agents. The goal of these studies is to identify the factors involved in nuclear reprogramming and to adjust in vitro manipulations in order to better mimic in vivo conditions. Therefore, proper knowledge of epigenetic reprogramming is necessary to prevent possible epigenetic errors and to improve efficiency and the use of in vitro fertilization and cloning technologies in cattle and other species.
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