Transcriptional Elongation and mRNA Export Are Coregulated Processes | Zendy

Maria Micaela MolinaNavarro | Zendy; Celia Pilar MartinezJimenez | Zendy; Susana RodríguezNavarro | Zendy

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Transcriptional Elongation and mRNA Export Are Coregulated Processes

Author(s) -

Maria Micaela MolinaNavarro,

Celia Pilar MartinezJimenez,

Susana RodríguezNavarro

Publication year - 2011

Publication title -

genetics research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.351

H-Index - 9

eISSN - 2090-3154

pISSN - 2090-3162

DOI - 10.4061/2011/652461

Subject(s) - messenger rna , microbiology and biotechnology , cytoplasm , transcription (linguistics) , chromatin , gene expression , epigenetics , gene , biology , transcriptional regulation , regulation of gene expression , genetics , computational biology , linguistics , philosophy

Chromatin structure complexity requires the interaction and coordinated work of a multiplicity of factors at different transcriptional regulation stages. Transcription control comprises a set of processes that ensures proper balance in the gene expression under different conditions, such as signals, metabolic states, or development. We could frame those steps from epigenetic marks to mRNA stability to support the holistic view of a fine-tune balance of final mRNA levels through mRNA transcription, export, stability, translation, and degradation. Transport of mRNA from the nucleus to the cytoplasm is a key process in regulated gene expression. Transcriptional elongation and mRNA export are coregulated steps that determine the mature mRNA levels in the cytoplasm. In this paper, recent insights into the coordination of these processes in eukaryotes will be summarised.

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