A Factor Analytic Approach to Symptom Patterns in Dementia | Zendy

Lars Gustafson | Zendy; Catarina Erikson | Zendy; Siegbert Warkentin | Zendy; Arne Brun | Zendy; Elisabet Englund | Zendy; Ulla Passant | Zendy

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A Factor Analytic Approach to Symptom Patterns in Dementia

Author(s) -

Lars Gustafson,

Catarina Erikson,

Siegbert Warkentin,

Arne Brun,

Elisabet Englund,

Ulla Passant

Publication year - 2010

Publication title -

international journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.657

H-Index - 49

eISSN - 2090-8024

pISSN - 2090-0252

DOI - 10.4061/2011/632604

Subject(s) - frontotemporal dementia , exploratory factor analysis , rating scale , medical diagnosis , medicine , dementia , disease , clinical dementia rating , clinical psychology , vascular dementia , construct validity , psychiatry , psychometrics , psychology , pathology , developmental psychology

Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n=74), VaD (n=33), mixed AD/VaD (n=31), or FTD (n=52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales

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