Age-Related White Matter Changes | Zendy

Yunyun Xiong | Zendy; Vincent Mok | Zendy

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Age-Related White Matter Changes

Author(s) -

Yunyun Xiong,

Vincent Mok

Publication year - 2011

Publication title -

journal of aging research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.564

H-Index - 43

eISSN - 2090-2212

pISSN - 2090-2204

DOI - 10.4061/2011/617927

Subject(s) - medicine , dementia , depression (economics) , epidemiology , disease , cognitive impairment , stroke (engine) , vascular dementia , cognitive decline , white matter , physical medicine and rehabilitation , gerontology , intensive care medicine , magnetic resonance imaging , mechanical engineering , radiology , engineering , economics , macroeconomics

Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. In this paper, we reviewed the current understanding in the pathophysiology, epidemiology, clinical importance, chemical biomarkers, and treatments of age-related WMC.

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