Modelling Tauopathies inDrosophila: Insights from the Fruit Fly | Zendy

Catherine M. Cowan | Zendy; Megan Sealey | Zendy; Shmma Quraishe | Zendy; Marie-Therese Targett | Zendy; Kristen A. Marcellus | Zendy; Douglas W. Allan | Zendy; Amritpal Mudher | Zendy

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Modelling Tauopathies inDrosophila: Insights from the Fruit Fly

Author(s) -

Catherine M. Cowan,

Megan Sealey,

Shmma Quraishe,

Marie-Therese Targett,

Kristen A. Marcellus,

Douglas W. Allan,

Amritpal Mudher

Publication year - 2011

Publication title -

international journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.657

H-Index - 49

eISSN - 2090-8024

pISSN - 2090-0252

DOI - 10.4061/2011/598157

Subject(s) - drosophila (subgenus) , on the fly , medicine , data science , biology , computer science , genetics , operating system , gene

Drosophila melanogaster is an experimentally tractable model organism that has been used successfully to model aspects of many human neurodegenerative diseases. Drosophila models of tauopathy have provided valuable insights into tau-mediated mechanisms of neuronal dysfunction and death. Here we review the findings from Drosophila models of tauopathy reported over the past ten years and discuss how they have furthered our understanding of the pathogenesis of tauopathies. We also discuss the multitude of technical advantages that Drosophila offers, which make it highly attractive as a model for such studies.

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