Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis | Zendy

Khavinson VKh | Zendy; V. О. Polyakova | Zendy; N. S. Linkova | Zendy; А. В. Дудков | Zendy; I. М. Kvetnoy | Zendy

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Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis

Author(s) -

Khavinson VKh,

V. О. Polyakova,

N. S. Linkova,

А. В. Дудков,

I. М. Kvetnoy

Publication year - 2011

Publication title -

journal of amino acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.188

H-Index - 5

eISSN - 2090-0112

pISSN - 2090-0104

DOI - 10.4061/2011/517137

Subject(s) - apoptosis , microbiology and biotechnology , cell growth , cellular differentiation , cortical neurons , biology , biochemistry , gene

The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells.

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