The Roles of ADAMs Family Proteinases in Skin Diseases | Zendy

Masakazu Kawaguchi | Zendy; Vincent J. Hearing | Zendy

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The Roles of ADAMs Family Proteinases in Skin Diseases

Author(s) -

Masakazu Kawaguchi,

Vincent J. Hearing

Publication year - 2011

Publication title -

enzyme research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.439

H-Index - 39

eISSN - 2090-0406

pISSN - 2090-0414

DOI - 10.4061/2011/482498

Subject(s) - disintegrin , proteolysis , metalloproteinase , transmembrane protein , biology , matrix metalloproteinase , cell adhesion , wound healing , immunoglobulin superfamily , microbiology and biotechnology , inflammation , cell adhesion molecule , cell migration , cell , cancer research , immunology , genetics , receptor , enzyme , biochemistry

A disintegrin and metalloproteinases (ADAMs) are members of a new gene family of transmembrane and secreted proteins, which belong to the zinc proteinase superfamily. These molecules are involved in various biological events such as cell adhesion, cell fusion, cell migration, membrane protein shedding, and proteolysis. Growing evidence now attests to the potential involvement of ADAMs proteinases in diverse processes such as skin wound healing, inflammation, pigmentation, tumor development, cell proliferation, and metastasis. This paper focuses on the roles of ADAMs proteinases in a wide variety of skin diseases

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