Doubts and Concerns about Isolated Maternal Hypothyroxinemia | Zendy

Mariacarla Moleti | Zendy; Francesco Trimarchi | Zendy; Francesco Vermiglio | Zendy

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Doubts and Concerns about Isolated Maternal Hypothyroxinemia

Author(s) -

Mariacarla Moleti,

Francesco Trimarchi,

Francesco Vermiglio

Publication year - 2011

Publication title -

journal of thyroid research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 31

eISSN - 2090-8067

pISSN - 2042-0072

DOI - 10.4061/2011/463029

Subject(s) - medicine , offspring , thyroid function , thyroid disease , thyroid , disease , pregnancy , endocrinology , pathology , biology , genetics

There is evidence that isolated maternal hypothyroxinemia may have detrimental effects on both mother and foetus. Nonetheless, this condition is still far from being universally accepted as a separate thyroid disease, and a standard definition of this state of mild thyroid underfunction is still lacking. We will review the biochemical criteria used to define isolated maternal hypothyroxinemia, together with current methodological issues related to FT4 assays. We will also discuss its epidemiological impact in both iodine-deficient and-sufficient areas, and the effectiveness of iodine prophylaxis on maternal thyroid function and neuropsychomotor development in offspring

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