Open AccessEGF and TGF-1 Effects on Thyroid Function
Author(s) -
Gabriella Mincione,
Maria Carmela Di Marcantonio,
Chiara Tarantelli,
Sonia D'inzeo,
Arianicolussi,
Francesco Nardi,
Caterina F. Donini,
Anna Coppa
Publication year - 2011
Publication title -
journal of thyroid research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 31
eISSN - 2090-8067
pISSN - 2042-0072
DOI - 10.4061/2011/431718
Subject(s) - transforming growth factor , thyroid , cancer research , thyroid cancer , receptor , medicine , signal transduction , malignant transformation , thyroid function , cell growth , transduction (biophysics) , suppressor , endocrinology , cell culture , cancer , biology , microbiology and biotechnology , genetics , biochemistry
Normal epithelial thyroid cells in culture are inhibited by TGF-1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF- responsiveness could be due to a reduced expression of TGF- receptors, as shown in transformed rat thyroid cell lines and in human thyroid tumors, or to alterations of other genes controlling TGF- signal transduction pathway. However, in thyroid neoplasia, a complex pattern of alterations occurring during transformation and progression has been identified. Functionally, TGF-1 acts as a tumor suppressor in the early stage of transformation or as a tumor promoter in advanced cancer. This peculiar pleiotropic behaviour of TGF- may result from cross-talk with signalling pathways mediated by other growth factors, among which EGF-like ligands play an important role. This paper reports evidences on TGF-1 and EGF systems in thyroid tumors and on the cross-talk between these growth factors in thyroid cancer
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