Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia | Zendy

Y. Kim | Zendy; Sharmilan Thanendrarajan | Zendy; Ingo G.H. SchmidtWolf | Zendy

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Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia

Author(s) -

Y. Kim,

Sharmilan Thanendrarajan,

Ingo G.H. SchmidtWolf

Publication year - 2011

Publication title -

leukemia research and treatment

Language(s) - English

Resource type - Journals

eISSN - 2090-3219

pISSN - 2090-3227

DOI - 10.4061/2011/428960

Subject(s) - wnt signaling pathway , myeloid leukemia , epigenetics , catenin , cancer research , biology , leukemia , medicine , bioinformatics , signal transduction , gene , immunology , genetics

Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.

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